Eugen Melcescu, Michael Griswold, Lianbin Xiang, Sheila Belk, Denise Montgomery, Marilyn Bray, Kevin S. Del Ben, Gabriel I. Uwaifo, Gailen D. Marshall, Christian A. Koch
OBJECTIVE: Polymorphisms (SNP) in the glucocorticoid receptor (GR) gene can alter sensitivity to glucocorticoids. Previous studies of the N363S and BclI SNP in the GR gene have shown a metabolic syndrome phenotype in mostly non-African populations. The obesity phenotype of African Americans …
Konstantinos Makrilakis, Sofia Grammatikou, Stavros Liatis, Meropi Kontogianni, Despoina Perrea, Charilaos Dimosthenopoulos, Kalliopi-Anna Poulia, Nicholas Katsilambros
OBJECTIVE: The aim of the present study was to evaluate the effectiveness of a non-intensive, community-based, lifestyle intervention program on the prevalence of metabolic syndrome (MS), in individuals at high risk for development of type 2 diabetes …
Kleopatra Alexiadou, Alexander Kokkinos, Stavros Liatis, Despoina Perrea, Nicholas Katsilambros, Nicholas Tentolouris
OBJECTIVE. Previous data suggest that apelin and visfatin play a role in metabolism and glucose homeostasis. The aim of the present study was to determine differences in plasma apelin and visfatin concentrations between healthy subjects and patients with type 1 diabetes mellitus …
Vittoria Rufini, Giorgio Treglia, Germano Perotti, Alessandro Giordano
Panagiota Pervanidou, Giorgos Chouliaras, Athanassios Akalestos, Despoina Bastaki, Filia Apostolakou, Ioannis Papassotiriou, George P. Chrousos
OBJECTIVE: Childhood obesity and the Metabolic Syndrome (MetS) are associated with an increased risk for early onset endothelial dysfunction and atherosclerosis. Placental growth factor (PlGF), a member of the vascular endothelial growth factor family, plays an important role in atherosclerosis by stimulating angiogenesis …
Mojca Jensterle, Nika Aleksandra Kravos, Marija Pfeifer, Tomaz Kocjan, Andrej Janez
OBJECTIVE: The long-acting glucagon-like peptide 1 receptor agonist liraglutide is linked to progressive and sustained weight loss in obese people with diabetes. However, its efficacy and safety in women with polycystic ovary syndrome (PCOS) has not yet been addressed …
Cristiano Roberto Grimaldi Barcellos, Michelle Patrocínio Rocha, Sylvia Asaka Yamashita Hayashida, Wagner Silva Dantas, Viviane dos Reis Vieira Yance, José Antonio Miguel Marcondes
OBJECTIVE: The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation—tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)—in young women without major cardiovascular (CV) risk factors …
Margarita Vlassi, Maria Gazouli, George Paltoglou, Panagiotis Christopoulos, Lina Florentin, Georgia Kassi, George Mastorakos
OBJECTIVE: To investigate the association between Gestational Diabetes Mellitus (GDM) and the variants rs10830963 and rs1387153 in the MTNR1B locus in a sample of the Greek population. DESIGN: One hundred seventy-five unrelated pregnant Greek women …
Irini Dermitzaki, Christos Tsatsanis, Vassiliki-Ismini Alexaki, Elias Castanas, Andrew N. Margioris
Corticotropin-releasing hormone (CRH) affects cytosolic calcium ion levels. The aim of the present work was to examine the role of protein kinase A (PKA)- and PKC-dependent signalling pathways in mediating the effect of CRH on calcium ion influx (from extra-cellular sources) and calcium ion mobilization (from intra-cellular stores)…
Peter D. Papapetrou
OBJECTIVE: To assess the relationship between circulating 25(OH)D, 1,25(OH)2D, and 24,25(OH)2D in pregnancy at term, and to test the hypothesis that serum 25(OH)D and 24,25(OH)2D are repressed by high serum 1,25(OH)2D levels …
Biljana Nedeljkovic Beleslin, Jasmina Ciric, Milos Zarkovic, Mirjana Stojkovic, Slavica Savic, Miroslav Knezevic, Branislav Stankovic, Bozo Trbojevic
OBJECTIVE: Glucocorticoids (GC) are the treatment of choice for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still . The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period …
Mirjam Christ-Crain, Christian Meier, Peter Huber, Henryk Zulewski, Jean-Jacques Staub, Beat Müller
Background: In overt hypothyroidism (OH) anemia is common, while less frequently basophilia has been described. In subclinical hypothyroidism (SCH), however, data on the distribution of peripheral blood cells are lacking. Therefore, we evaluated the effects of L-T4 replacement therapy on peripheral blood elements in female patients with SCH before and after restoration …
Vassiliki Syriou, Anestis Moisidis, Nikolaos Tamouridis, Krystallenia I. Alexandraki, Margarita Anapliotou
We present a 73-year-old man with isolated adrenocorticotropic hormone deficiency and “flexion contractures” syndrome along with a review of the relevant literature. The patient initially presented anorexia, vomiting, arthralgias, malaise, and weight loss, which progressively deteriorated during the subsequent 6 months. He was admitted to the hospital with fever, confusion, severe cachexia, sinus tachycardia, low blood pressure …
Vladimir Jovanovic, Sandra Pekic, Marko Stojanovic, Goran Tasic, Branko Djurovic, Ivan Soldatovic, Mirjana Doknic, Dragana Miljic, Marina Djurovic, Milica Medic-Stojanoska, Vera Popovic
OBJECTIVE: Subarachnoid hemorrhage (SAH) is a recently identified risk factor for hypopituitarism, particularly growth hormone (GH) and corticotrophins deficiencies. The aim of our study was to identify possible predictor(s) for neuroendocrine dysfunction in SAH survivors. DESIGN: Pituitary function was evaluated in 93 patients …
Eftychia Koukkou, Stavros Kravaritis, Irene Mamali, Georgios G. Markantes, Marina Michalaki, Georgios G. Adonakis, Neoklis A. Georgopoulos, Kostas B. Markou
OBJECTIVE: Adequate dietary iodine intake is necessary for normal thyroid gland function at all times, and most particularly during pregnancy. Increased iodine loss is cited, among other factors, as responsible for the increased iodine demand in this period. Our aim was to compare renal iodine excretion between …
Michael Hermanussen
The ancestors of modern Europeans arrived in Europe at least 40,000 years before present. Pre-glacial maximum Upper Palaeolithic males (before 16,000 BC) were tall and slim (mean height 179 cm, estimated average body weight 67 kg), while the females were comparably small and robust (mean height 158 cm, estimated average body weight 54 kg) …
Stavros N. Karamanakos, Kostas B. Markou, Konstantinos Panagopoulos, Dionisios Karavias, Constantinos E. Vagianos, Chrisoula D. Scopa, Vassiliki Fotopoulou, Anna Liava, Konstantinos Vagenas
OBJECTIVE: To evaluate the rate of complications and the risk factors in relation to the extent of surgery in patients undergoing thyroidectomy in a tertiary university center. DESIGN: Data were collected retrospectively from 2,043 consecutive patients who underwent thyroid surgery for various thyroid diseases at the University Hospital of Patras …
Maria G. Grammatikopoulou, Eleni P. Kotanidou, Anastasia G. Markaki, Charilaos Stylianou, Assimina Galli-Tsinopoulou, Maria Tsigga, Maria Hassapidou
OBJECTIVE: The aim of the present study was to evaluate by pooled and sensitivity analyses all available data on adolescent overweight/obesity in Cyprus. DESIGN: A thorough literature search determined the studies to be examined using Cypriot adolescent samples …
Assimina Galli-Tsinopoulou, Sanda Nousia-Arvanitakis, Ioannis Tsinopoulos, Christos Bechlivanides, Orit Shevah, Zvi Laron
Laron-type dwarfism is an autosomal recessive disorder caused by deletions or mutations of the growth hormone receptor gene. It is characterized by high circulating levels of growth hormone (GH) and low levels of insulin-like growth factor I (IGF-I). Patients are refractory to both endogenous and exogenous GH, and present severe growth retardation and obesity …
Charilaos Stylianou, Assimina Galli-Tsinopoulou, Maria G. Grammatikopoulou, George Koliakos, George Varlamis
Objective: The exact role of ghrelin in the control of growth hormone (GH) secretion has not been completely clarified as yet. The aim of the present study was 1) to investigate the effect of a substance promoting GH secretion (clonidine) on ghrelin levels in children with short stature with growth hormone deficiency (GHD) and normal growth hormone …
Olga Papalou, Sarantis Livadas, Athanasios Karachalios, Nikoleta Tolia, Panayiotis Kokkoris, Konstantinos Tripolitakis, Evanthia Diamanti-Kandarakis
Fotini Psychou, Polyxeni Nicolaidou, Helen Georgouli, Maria Maniati-Christidis, Catherine Dacou-Voutetakis
We report a boy with pseudohypoparathyroidism (PHP), hypothyroidism and low growth hormone (GH) values with no response to growth hormone releasing hormone (GHRH). He presented at age 17 mo because of developmental delay. He had the typical features (short stature, obesity, round face, brachydactyly) of Albright’s hereditary osteodystrophy (AHO) …