Andrew (Andy) N. Margioris
With this first issue of HORMONES for 2013, we celebrate 12 years of continuous publication. The Journal HORMONES has been listed in Pubmed since 2005 and its current impact factor is 2.4 …
Journal Articles
Growth Management of Children and Adolescents with Cushing’s Disease
In this issue, Savage et al., summarize and discuss their data and those of the literature on the growth management of pediatric patients with Cushing’s disease. Endogenous Cushing’s syndrome is rare in all ages and children and adolescents represent about 10 percent of the total …
Muscular effects of vitamin D in young athletes and non-athletes and in the elderly
Nikolaos E. Koundourakis, Pavlina D. Avgoustinaki, Niki Malliaraki, Andrew N. Margioris
Muscles are major targets of vitamin D. Exposure of skeletal muscles to vitamin D induces the expression of multiple myogenic transcription factors enhancing muscle cell proliferation and differentiation. At the same time vitamin D suppresses the expression of myostatin, a negative regulator of muscle mass …
Hoarseness after thyroidectomy: Blame the endocrine surgeon alone?
Demetrios Moris, Eleftherios Mantonakis, Marinos Makris, Adamantios Michalinos, Spiridon Vernadakis
OBJECTIVE: Hoarseness is a postoperative complication of thyroidectomy, mostly due to damage to the recurrent laryngeal nerve (RLN). Hoarseness may also be brought about via vocal cord dysfunction (VCD) due to injury of the vocal cords from manipulations during anesthesia, as well as from psychogenic disorders …
Comments on gestational diabetes mellitus: from pathophysiology to clinical practice
Pavlos Poulakos, Gesthimani Mintziori, Efrosini Tsirou, Eleftheria Taousani, Dimitra Savvaki, Vikentia Harizopoulou, Dimitrios G. Goulis
Gestational diabetes mellitus (GDM) is a topic of major interest, as it affects up to 16% of pregnant women and may lead to adverse pregnancy outcomes, which, however, are preventable by appropriate treatment. The aim of the present study was to discuss basic concepts and to critically appraise recent updates on practical issues …
Liquid levothyroxine and its potential use
Anna Maria Formenti, Linda Daffini, Ilenia Pirola, Elena Gandossi, Alessandra Cristiano, Carlo Cappelli
Editorial
Aleksander Giwercman, Dimitrios G. Goulis, Ilpo Huhtaniemi, Christos Tsatsanis
This issue of HORMONES is dedicated to the Symposium “Endocrine Aspects in Andrology” that took place in Heraklion, Crete, Greece, on 13-15 March, 2015 …
Adrenal Incidentalomas or Adrenalomas: The NIH state-of-the-science conference statement
Editorial
In this issue of Hormones, Dr. Dimitrios Linos has written a comprehensive review on adrenal incidentalomas, for which he proposes the more economical term “adrenalomas”. The management of these incidentally discovered, common masses has many controversies stemming from the fact that a minute proportion of them can be malignant …
Data Mining: A New Technique In Medical Research
Eirini Papageorgiou, Ioanna Kotsioni, Athena Linos
This issue hosts an article that discusses the application of Data mining techniques to the treatment of infertile men with azoospermia, and compares this procedure of categorisation into groups with the corresponding clinical categorisation…
Wylie Walker Vale, Jr.
George P. Chrousos, Achille Gravanis, Andrew (Andy) N. Margioris
Wylie Walker Vale, Jr. was born in Houston, Texas, on July 3, 1941. While still in high school, he met and fell in love with his wife Betty to whom he was married for over 40 years. Wylie earned his bachelor’s degree in Biology …
Expression of somatostatin receptors may guide the use of somatostatin receptor imaging and therapy in differentiated thyroid cancer
Giorgio Treglia, Guido Rindi, Vittoria Rufini
Thyroid carcinoma is the most frequent type of endocrine tumour. Most differentiated thyroid cancers (DTCs) have an excellent prognosis if diagnosed early and treated appropriately. Nevertheless, a number of patients with DTCs do not achieve remission after thyroidectomy …
Normocalcemic primary hyperparathyroidism: A newly emerging disease needing therapeutic intervention
Gonzalo Díaz-Soto, María Teresa Julián, Manel Puig-Domingo
Normocalcemic primary hyperparathyroidism (NCHPT) is a new entity which possibly represents a “fruste form” of classic clinically symptomatic hyperparathyroidism. Over the last decade it has generated considerable scientific interest …
Editor’s Note
Andrew N. Margioris
From the Editor
Andrew N. Margioris
We welcome you to the 2013 third trimester issue of Hormones! In this issue, the Reviews section includes four papers …
Oral glucose lowering drugs in type 2 diabetic patients with chronic kidney disease
Cláudia Nogueira, Selma B. Souto, Eduardo Vinha, Daniel Carvalho-Braga, Davide Carvalho
Chronic kidney disease (CKD) represents a challenge in the treatment of type 2 diabetic patients. Renal impairment may affect drug clearance and other pharmacokinetic processes which can increase toxicity and drug to drug interactions or cause ineffective therapy …
Letter from the Editor
C. Dacou-Voutetakis
Dear Colleague, “HORMONES”, the new peer reviewed International Journal of Endocrinology and Metabolism, has finally been born. Every creation is marked by birth followed by growth and maturation, and we hope that our Journal will follow these evolutionary steps…
Macroprolactinemia: an unnoticeable factor
Hyperprolactinemia most commonly results from physiologic or pathologic conditions that cause hypersecretion of PRL by lactotroph cells. Physiologic causes include pregnancy and lactation while pathologic hyperprolactinemia may result from a lactotroph adenoma or from several readily identifiable causes that may interfere with normal dopamine inhibition of PRL secretion. However, in some patients whose serum PRL …
Estrogens and brain function
Athina Markou, Theodora Duka, Gordana M. Prelevic
Cognitive decline is well recognized during ageing but is often accelerated in women after menopause. Studies have shown that there are significant gender differences in brain ageing with significantly greater changes in brain structure, function and metabolism between females and males. Estrogens exert protective effects on neuronal cells in culture but the exact underlying …
The spectrum of phytoestrogens in nature: our knowledge is expanding
Paraskevi Moutsatsou
The classical phytoestrogens, so far known, constitute a group of plant-derived compounds which include mainly isoflavones, lignans, coumestanes, stilbenes and the flavonoids quercetin and kaempherol. The discovery of many more novel estrogen-like compounds in the plant kingdom demonstrates that the spectrum of phytoestrogens in nature is expanding …
Targeting the osteoblast: approved and experimental anabolic agents for the treatment of osteoporosis
Konstantinos A. Toulis, Athanasios D. Anastasilakis, Stergios A. Polyzos, Polyzois Makras
Targeting osteoblast may be the means of effectively improving both bone quality and mass, thus offering an intriguing alternative in the treatment of osteoporosis. Aside from injectable parathyroid hormone (PTH) and its novel preparations, PTH-related peptide (PTHrP), calcilytics …
Effect of maternal obesity on pregnancy outcomes and long-term metabolic consequences
Georgios Valsamakis, Evagelia L. Kyriazi, Zadalla Mouslech, Charalampos Siristatidis, George Mastorakos
Recent years have witnessed a worldwide increase in the prevalence of pre-pregnancy maternal obesity. A survey carried out in the USA between 2003 and 2006 reported that 32% of women aged 20-44 years were classified as obese (WHO 2009) …
Exercise and the Stress System
George Mastorakos, Maria Pavlatou, Evanthia Diamanti-Kandarakis, George P. Chrousos
Exercise represents a physical stress that challenges homeostasis. In response to this stressor, autonomic nervous system and the hypothalamic-pituitary-adrenal axis are known to react and to participate in the maintenance of homeostasis. This includes elevation of cortisol and cathecholamines in plasma. However, sustained physical conditioning in highly trained athletes is associated…
Thyroid cancer in childhood: Management strategy, including dosimetry and long-term results
Markus Luster, Michael Lassmann, Lutz S. Freudenberg, Christoph Reiners
Thyroid cancer, although very rare in childhood, represents the most common pediatric endocrine neoplasia. The low incidence and the resulting limited availability of prospective, randomized trials lead to a lack of evidence- based recommendations for treatment strategies. Total thyroidectomy and lymphadenectomy …
Diagnosis and management of hyperglycemic emergencies
Niyutchai Chaithongdi, Jose S. Subauste, Christian A. Koch, Stephen A. Geraci
This article is aimed at providing a practical up-to-date review of the precipitating factors, diagnosis, management and secondary prevention of hyperglycemic emergencies (diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) to assist critical care physicians and hospitalists caring for these patients …
A short evolutionary history of FSH-stimulated spermatogenesis
Ilpo Huhtaniemi
It is well established in various experimental models that luteinizing hormone (LH) stimulated testosterone (T) production of Leydig cells is the key endocrine stimulus of spermatogenesis. The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions …