Niki Katsiki, Genovefa Kolovou
We read with interest the Pappas et al review on postprandial dysmetabolism. The authors describe evidence linking elevated levels of postprandial glucose and triglycerides (TGs) with cardiovascular (CV) morbidity and mortality as well as with polycystic ovary syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD) …
Olga V. Fofanova, Oleg V. Evgrafov, Alexander V. Polyakov, Valentina A. Peterkova, Ivan I. Dedov
Isolated Growth Hormone Deficiency (IGHD) due to GH1 gene defects has a variable inheritance pattern: autosomal recessive, autosomal dominant, and X-linked. the autosomal dominantly inherited form, IGHD II, is mainly caused by heterozygous mutations of splicing around the exon 3/IVs3 boundary region of the GH1 gene resulting in exon 3 skipping of transcripts …
Labrini Papanastasiou, Theodora Pappa, Aikaterini Dasou, Efi Kyrodimou, George Kontogeorgos, Christianna Samara, Panagiotis Bacaracos, Athanasios Galanopoulos, George Piaditis
OBJECTIVE: Primary central nervous system (CNS) non-Hodgkin’s lymphoma is a rarely encountered clinical entity. Here we present a case of a primary CNS diffuse large B-cell non-Hodgkin’s lymphoma developed on a previously operated and irradiated pituitary macroadenoma. DESIGN-RESULTS: A 60-year-old woman presented with muscle weakness …
Snezana P. Polovina, Dragana Miljic, Sladjana Zivojinovic, Natasa Milic, Dragan Micic, Vera Popovic Brkic
OBJECTIVE: Skeletal development, linear growth, cartilage biology and bone turnover are highly dependent on the activity of thyroid hormones. Thyroid dysfunction affects the skeleton, and autoimmune thyroid disease, manifesting as a chronic inflammatory condition, may be an important contributing factor to impaired bone quality in these patients. MATERIALS AND METHODS: Measurement of TSH, FT4, TPOAb and bone mineral density and FRAX score calculations were performed …
Konstantinos Terzidis, Panagoula Tourli, Erasmia Kiapekou, Maria Alevizaki
Although the association of thyroid disorders with tuberculosis has been known for a long time, the diagnosis of thyroid tuberculosis is rare. Differential diagnosis can be very difficult without fine needle aspiration. The clinical course of the disease may resemble toxic goiter or acute thyroiditis or may follow a subacute or chronic pattern without specific symptomatology…
Maria Andrikoula, Amalia Sertedaki, Sofia Andrikoula, Catherine Dacou-Voutetakis, Agathocles Tsatsoulis
PROP-1 gene mutations have been reported as a cause of combined pituitary hormone deficiency. Physical and hormonal phenotypes of affected individuals are variable. We report a 63-year-old female who presented with osteoporosis
Maria P. Yavropoulou, Alexandros Michopoulos, John G. Yovos
Parathyroid hormone receptors are present in bone cells and play a crucial role in the maintenance of skeletal integrity, bone homeostasis and regulation of calcium and phosphate metabolism. Although the function of these receptors has long being recognized in the cells of the osteoblastic lineage regulating directly osteoblast differentiation and function and indirectly osteoclastogenesis …
Asteroula Papathanasiou, Eleni Kousta, Vasiliki Skarpa, Petros Papachileos, Vasilios Petrou, Charalambos Hadjiathanasiou
Autoimmune polyglandular syndrome (APs) type 2 is characterized by the presence of Addison’s disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus and is rare in children. A 12.5yr old prepubertal boy presented with symptoms related to Addison’s disease and a large goiter. He was euthyroid with positive thyroid antibodies, low cortisol, aldosterone and very high adrenocorticotropin …
Noel P. Somasundaram, Chaminda Garusinghe, Dan Berney, Ashley B. Grossman
Cushings’s syndrome due to ectopic adrenocorticotrophin (ACTH) secretion was first described nearly a century ago by Hurst Brown. Bronchial carcinomas, usually bronchial carcinoids, were the first to be described and continue to be the leading cause of the ectopic ACTH syndrome …
Eirini Dermitzaki, Pavlina D. Avgoustinaki, Eirini C. Spyridaki, Panagiotis Simos, Niki Malliaraki, Maria Venihaki, Christos Tsatsanis, Andrew N. Margioris
OBJECTIVE: Adiponectin is the major product of adipose tissue. The aim of this study was to associate adiponectin levels with adipose tissue and metabolic indices. DESIGN: Plasma samples of 274 non-diabetic volunteers were collected to evaluate for adiponectin, inflammatory markers, insulin and lipid parameters. Body fat composition was measured by DEXA. RESULTS: As expected, adiponectin levels correlated with body mass index (BMI) …
Assimina Galli-Tsinopoulou, Eleftheria Emmanouilidou, Paraskevi Karagianni, Maria Grigoriadou, John Kirkos, George S. Varlamis
Silver Russell Syndrome (SRS) is a rare condition (1/3000 – 1/100,000 newborns). We present a female infant with SRS, cardiac malposition and asymmetric enlargement of the clitoris. She is the first child of Greek nonconsanguinous parents, born at 38 weeks gestation …
Kalliopi Lampropoulou-Adamidou, Symeon Tournis, Alexia Balanika, Ioulia Antoniou, Ioannis P. Stathopoulos, Christos Baltas, Ioannis K. Triantafillopoulos, Nikolaos A. Papaioannou
OBJECTIVE: Despite the existence of numerous case series, no evidenced-based medical management for atypical fractures associated with bisphosphonate (BP) treatment has been established. DESIGN: We report the outcome of teriparatide (TRP) administration followed …
Maria Chantal Ponziani, Ioannis Karamouzis, Chiara Mele, Luisa Chasseur, Marco Zavattaro, Marina Caputo, Maria Teresa Samà, Arianna Busti, Loredana Pagano, Luigi Castello, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam
OBJECTIVE. We evaluated the risk of altered glucose levels and new-onset diabetes (NOD) associated with statins according to glucose levels at baseline in a population treated for dyslipidemia on primary prevention for >5 years. DESIGN. The retrospective study included 308 subjects (265 on statins and 43 controls on diet) with a follow-up of 5-15 years …
Gideon de Sousa, Rainer Wunsch, Werner Andler
We report the findings and clinical course of ten girls aged 0.2 to 6.3 years with precocious pseudopuberty due to autonomous ovarian cysts. We found elevated oestrogen levels in five patients and failure of gonadotropin response to GnRH stimulation in four patients during the first episode, of the disease …
Anastasia Sfikakis, Pothitos M. Pitychoutis, Aikaterini Tsouma, Ioanna Messari, Zeta Papadopoulou-Daifoti
OBJECTIVE: To examine the impact of circulating testosterone (T) and the T/Estradiol (T/Ediol) ratio on chronic stress-induced changes of adrenal and hippocampal weight during proestrus (PE) and estrus (E) in female rats. DESIGN: Stress was composed of repeated vaginal smear screening (VSS) and measured by the emotional reactivity score …
Ibrahim Nasiru Akanmu, Oludara Mobolaji Adewale
Multiple thyroid ectopia with a normally located thyroid gland is a very rare condition. We present a 34-year old Nigerian woman who had had anterior and left-sided lateral neck swellings for the past 15 years …
Makarios Eleftheriades, Panagiota Pervanidou, Homeira Vafaei, George Vaggos, Ismene Dontas, Katerina Skenderi, Neil J. Sebire, Kypros Nicolaides
OBJECTIVE: This experimental study aimed to prospectively investigate the impact of combinations of prenatal and postnatal food manipulations on the metabolic profile of adult offspring. DESIGN: On day 12 of gestation, 67 timed pregnant rats were randomized into three nutritional groups …
Sena Yesil, Baris Akinci, Serkan Yener, Firat Bayraktar, Ozalp Karabay, Hasan Havitcioglu, Nur Yapar, Atay Atabey5 Yasin Kucukyavas, Abdurrahman Comlekci, Sevinc Eraslan
OBJECTIVE: Prediction of diabetic foot ulcer outcome may be helpful for clinicians in optimizing and individualizing management strategy. The aim of the present study was to examine the possibility of predicting the outcome of patients with diabetic foot ulcers by using easily assessed clinical and laboratory parameters at baseline …
Aleksandra Rojek, Maciej Flader, Elzbieta Malecka, Marek Niedziela
OBJECTIVE: X-linked Adrenal Hypoplasia Congenita (AHC) is a rare disorder caused by mutations in NR0B1 (DAX1) gene. DESIGN: We present two boys (cousins) with AHC who came to our attention at the age of 10 days and 15 days, respectively, in a life-threatening state …
Georgia Kostopanagiotou, Konstantinos Kalimeris, Kalliopi Christodoulaki, Constantinos Nastos, Nikolaos Papoutsidakis, Cleanthi Dima, Charalampos Chrelias, Ageliki Pandazi, Iordanis Mourouzis, Constantinos Pantos
OBJECTIVE: To compare the effects of various anaesthetics on stress response in the presence and absence of surgical stimulation. DESIGN: Twenty-nine pigs scheduled to undergo surgical central vein catheter placement were randomly allocated to receive only sedation with ketamine-midazolam (group SHAM, n=5) or general anaesthesia …
Francesco Vierucci, Graziano Cesaretti
Autoimmune thyroiditis is considered to be the most common autoimmune condition, with a female preponderance of 2:1. While its overall prevalence peaks in adulthood, autoimmune thyroiditis may affect children and adolescents, particularly during early to mid-puberty …
Eirini Bathrellou, Mary Yannakoulia, Katerina Papanikolaou, Artemios Pehlivanidis, Panagiota Pervanidou, Christina Kanaka-Gantenbein, Ioanna Tokou, John Tsiantis, George P. Chrousos, Labros S. Sidossis
OBJECTIVE: To evaluate the effectiveness of active parental involvement in a lifestyle intervention for the management of childhood obesity. DESIGN: Forty-two overweight children (32 girls and 10 boys), aged 9.2±0.2 years and with percent overweight 39.8±2.7%, were randomly allocated either to a child-and-parent group …
Stelios Fountoulakis, Dimosthenis Malliopoulos, Labrini Papanastasiou, Theodora Pappa, George Karydas, George Piaditis
OBJECTIVE: Non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) is one of the rare causes of endogenous hyperinsulinism. Its diagnosis is challenging and may require selective intraarterial calcium stimulation and concomitant hepatic vein sampling (SACVS). Impaired counterregulatory hormones’ production in response to hypoglycemia …
Nikiforos Ballian, Ioannis I. Androulakis, Klio Chatzistefanou, Christianna Samara, Konstantinos Tsiveriotis, Gregory A. Kaltsas
Radiation-induced optic neuropathy is a rare adverse effect of radiotherapy applied for the treatment of pituitary adenomas. We report a patient with a recurrent adrenocorticotrophin secreting pituitary adenoma who received external beam irradiation after failing surgical and medical therapy …
Eleonora Monti, Lorenzo Mortara, Simonetta Zupo, Mariella Dono, Francesco Minuto, Mauro Truini, Mehrdad Naseri, Massimo Giusti
After removal of an ovarian mass in a 43-year-old woman, a struma ovarii was diagnosed. Within this teratoma, a papillary thyroid cancer was found. The tumor was negative for BRAF, NRAS, KRAS, PIK3CA and c-KIT mutations on molecular analysis …