Journal Articles
Muscle strength and bone in healthy women: effect of age and gonadal status
Cristiana Cipriani, Elisabetta Romagnoli, Vincenzo Carnevale, Ida Raso, Addolorata Scarpiello, Maurizio Angelozzi, Andrea Tancredi, Stefania Russo, Federica De Lucia, Jessica Pepe, Salvatore Minisola
OBJECTIVE: The aim of this work was to examine the effects of age and menopause on muscle strength and on the muscle-bone interaction. DESIGN: One hundred ninety-four healthy women (mean age 49.8 ± 12.6 SD years) were assessed …
Low vitamin D status is associated with hypothyroid Hashimoto’s thyroiditis
Dohee Kim
OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients …
A case of a prolactinoma resistant to dopamine agonists
Irene Vourliotaki, Ingrid Elizabeth Bonapart, Catherine Stamataki, Eva-Maria Tsapakis, Catherine Saridaki
Dopamine agonists are the drugs of choice in the treatment of prolactinomas, the most common type of pituitary adenomas. However, up to 25% of prolactinomas do not respond to these drugs and alternative treatments have to be considered. We describe a 37-year old female with a microprolactinoma who, although having received all available formulations of dopamine agonists …
Late-onset hypogonadism in men. Experience from the Turku Male Ageing Study (TuMAS)
Ilpo Huhtaniemi, Juuso I. Mäkinen, Antti Perheentupa, Olli T. Raitakari
Interest has arisen during the last 10 years as to the possible connection between the age-related decline in androgen production and symptoms of ageing in men. A new ageing-related syndrome with several descriptive names …
The predictive role of 24h RAIU with respect to the outcome of low fixed dose radioiodine therapy in patients with diffuse toxic goiter
Nishikant Damle, Chandrasekhar Bal, Praveen Kumar, Ramamohan Reddy, Deepali Virkar
Radioactive iodine uptake (RAIU) is a test used to differentiate hyperthyroidism from thyroiditis and to calculate the radioiodine dose for treatment of Graves’ disease. We aimed to evaluate the predictive role of 24h RAIU with respect to the outcome of radioiodine therapy in patients with diffuse toxic goiter …
Severe osteoporosis with multiple spontaneous vertebral fractures in a young male carrying triple polymorphisms in the vitamin D receptor, collagen type 1, and low-density lipoprotein receptor-related peptide 5 genes
Maria P. Yavropoulou, Panagoulia Kollia, Dimitris Chatzidimitriou, Stavroula Samara, Lemonia Skoura, John G. Yovos
Osteoporosis is a common disease with a strong genetic component. Several studies have reported the vitamin D receptor (VDR), collagen type I (COL1A1), and LDL receptor-related protein 5 (LRP5) genes as the most likely candidates. However, most of the studies have been carried out in postmenopausal women and older men and show inconsistent results …
R831X mutation of the androgen receptor gene in an adolescent with Complete Androgen Insensitivity Syndrome and bilateral testicular hamartomata
Dimitrios G. Goulis, Paschalia K. Iliadou, Athanasios Papanicolaou, Ioannis Georgiou, Anthi Chatzikyriakidou, Spiridon Gerou, Ioannis N. Bontis, Ioannis Papadimas
An 18-year old, phenotypically female individual was examined for primary amenorrhea. Three months before her referral, the patient underwent surgery and a pelvic mass was removed. The physical examination revealed normal female external genitalia, normal breast development, sparse pubic hair and absence of axillary hair…
IGF-I generation test in prepubertal children with Noonan syndrome due to mutations in the PTPN11 gene
Silvano Bertelloni, Giampiero I. Baroncelli, Eleonora Dati, Silvia Ghione, Fulvia Baldinotti, Benedetta Toschi, Paolo Simi
BACKGROUND: Short stature represents one of the main features of children with Noonan syndrome. The reason for impaired growth remains largely unknown. OBJECTIVE: To assess GH and IGF1 secretion in children with Noonan syndrome …
Factors influencing the outcome of microsurgical transsphenoidal surgery for pituitary adenomas: A study on 184 patients
Kostas I. Lampropoulos, George Samonis, Panagiotis Nomikos
OBJECTIVE: Evaluation of factors influencing the outcome of microsurgical transsphenoidal surgery in patients harbouring pituitary adenomas as well as of the efficacy and safety of this procedure. DESIGN: A total of 184 consecutive patients with pituitary adenomas …
Clinical utility of FDG-PET for diagnosis of adrenal mass: a large single-center experience
Allison Pitts, Grace Ih, Meng Wei, Deepti Dhall, Nicholas N. Nissen, Alan Waxman, Run Yu
OBJECTIVE: To examine the clinical utility of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) for diagnosing whether an adrenal mass is malignant, in contemporary clinical practice. DESIGN: Retrospective medical record review of patients from 2 databases at a large hospital …
A novel mutation of the calcium-sensing receptor gene in a German subject with familial hypocalciuric hypercalcemia and primary hyperparathyroidism
Marios Papadakis, Natalie Meurer, Theodora Margariti, Anke Meyer, Norbert Weyerbrock, Cornelia Dotzenrath
OBJECTIVE: The coexistence of familial hypocalciuric hypercalcemia (FHH) and primary hyperparathyroidism (PHPT) is extremely rare. Genetic evidence has demonstrated a causal relationship between FHH and the presence of inactivating mutations in the calcium-sensing receptor gene …
Effect of hyperglycemia and hyperinsulinemia on glutathione peroxidase activity in non-obese women with polycystic ovary syndrome
Ana Savic-Radojevic, Ivana Bozic Antic, Vesna Coric, Jelica Bjekic-Macut, Tanja Radic, Milos Zarkovic, Tatjana Djukic, Marija Pljesa-Ercegovac, Dimitrios Panidis, Ilias Katsikis, Tatjana Simic, Djuro Macut
OBJECTIVE: In order to gain deeper insight into molecular mechanisms underlying oxidative stress (OS) and its relation to insulin resistance and hyperandrogenemia, plasma markers of OS and antioxidant glutathione-peroxidase (GPX) activity were studied in non-obese polycystic ovary syndrome (PCOS) women via the oral glucose tolerance test …
Gonadotropin releasing hormone analog treatment in children with congenital adrenal hyperplasia complicated by central precocious puberty
Ayla Güven, Ayşe Nurcan Cebeci, Suna Hancili
OBJECTIVE: Congenital adrenal hyperplasia (CAH) can be complicated by central precocious puberty (CPP) in children, which may compromise final height. We aimed to evaluate the effect of gonadotropin-releasing hormone analog (GnRHa) therapy on growth in children with CAH …
Impact of cancer and cancer treatment on male fertility
Ioannis Vakalopoulos, Petros Dimou, Ioannis Anagnostou, Theodosia Zeginiadou
While cancer, and especially testicular cancer and Hodgkin’s disease, affects male fertility in many ways, the current increase of survival of male cancer patients of reproductive age or earlier has emerged as a new challenge to their subsequent ability to father children. Cancer treatments, including surgery, radiotherapy and chemotherapy …
Validity and reliability of the Greek version of the Diabetic Foot Ulcer Scale – Short Form (DFS-SF)
Nick Kontodimopoulos, Anastasia Veniou, Nicholas Tentolouris, Dimitris Niakas
OBJECTIVE: Diabetic foot ulcer is a critical and costly complication of diabetes mellitus. The aim of this study was to assess the psychometric properties of the Greek version of the diabetic foot ulcer scale – short form (DFS-SF). DESIGN: A sample of patients with diabetic foot ulcer (N=110) was surveyed with the DFS-SF …
Clinical Case Seminar. Peculiar prolactinomas in patients with pituitary developmental gene mutations: from an adult endocrinologist perspective
Mirjana Doknic, Sandra Pekic, Milorad Civcic, Vera Popovic
CONTEXT: Congenital hypopituitarism is a syndrome which is associated with single or multiple pituitary hormone deficiencies. Mutations in a number of developmental genes have been linked to combined pituitary hormone deficiencies, the most common being mutation in the pituitary …
Type 2 diabetes mellitus is associated with obesity, smoking and low socioeconomic status in large and representative samples of rural, urban, and suburban adult Greek populations
Nicholas Tentolouris, Alexandros Andrianakos, Georgios Karanikolas, Dimitrios Karamitsos, Panagiotis Trontzas, Petros Krachtis, Fotis Christoyannis, Elpiniki Tavaniotou, Zouboulio Nikolia, Evaggelia Kaskani, Leonidas Kontelis, Petros P. Sfikakis
OBJECTIVE: In this cross-sectional epidemiologic study we examined the association between type 2 diabetes mellitus and demographic, clinical, and socioeconomic parameters in large rural, urban and suburban populations of adult Greeks. DESIGN: Of the total target adult population …
Increased prevalence of growth hormone deficiency in patients with vernal keratoconjuntivitis; An interesting new association
Stefano Stagi, Neri Pucci, Laura di Grande, Cinzia de Libero, Roberto Caputo, Stefano Pantano, Salvatore Seminara, Maurizio de Martino, Elio Novembre
INTRODUCTION: Vernal keratoconjunctivitis (VKC) is a chronic conjunctivitis that mainly affects children living in temperate areas. The notable difference between genders and VKC’s resolution with puberty have persistently suggested a role of hormonal factors in VKC development. …
A SOX3 (Xq26.3-27.3) duplication in a boy with growth hormone deficiency, ocular dyspraxia, and intellectual disability: A long-term follow-up and literature review
Stefano Stagi, Elisabetta Lapi, Marilena Pantaleo, Giovanna Traficante, Sabrina Giglio, Salvatore Seminara, Maurizio de Martino
OBJECTIVE:SOX3 is located on the long arm of the X chromosome (Xq27.1) and both the under- and over-expression of this gene have been reported in cases of hypopituitarism with or without intellectual disabilities. Nevertheless, only a few cases have as yet been extensively described …
Multiple pituitary hormone abnormalities, fever, behavioral problems, seizures and apnoic spells in a 6-year old girl
Kyriaki Karavanaki, Andriani Divoli, Mehul Dattani, George Briassoulis, Virginia Theodorou, Vasiliki Hatzara, Spyros Avlonitis
A 6-year old girl was examined having two years previously presented a transient Cushing’s syndrome, followed by recurrent hyponatremia, attributed to inappropriate ADH secretion (SIADH). The brain MRI showed no abnormalities on repeated examinations, except for a suggestion of empty sella syndrome. During the past two years she also presented recurrent episodes of a prolonged febrile illness of unknown origin…
A boy with McCune-Albright syndrome associated with GH secreting pituitary microadenoma. Clinical findings and response to treatment
Maria Papadopoulou, Sofia Doula, Kostas Kitsios, Themistoklis Kaltsas, Konstantina Kosta
The McCune-Albright Syndrome (MAS) is a sporadic rare disease first described in 1936 by McCune and separately by Albright. MAS is characterized by a triad of physical signs: café-au-lait spots, polyostotic fibrous dysplasia and autonomous endocrine hyperfunction. MAS is predominantly observed in girls and is rarely reported in males…
The effect of Dehydroepiandrosterone on insulin resistance in patients with impaired glucose tolerance
Afsaneh Talaei, Masoud Amini, Mansour Siavash, Maryam Zare
OBJECTIVE: Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEA-S) are the most abundant steroid hormones in the body. Recently, DHEA-S has gained interest as an antidepressant substance, with positive effects on autoimmune disease such as lupus and ulcerative colitis, as well as obesity, cancer, cardiovascular disease and diabetes …
The influence of combined oral contraceptives containing drospirenone on hypothalamic-pituitary-adrenocortical axis activity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome
Djuro Macut, Ivana Božić Antić, Jelena Nestorov, Vladanka Topalović, Jelica Bjekić Macut, Dimitrios Panidis, Biljana Kastratović Kotlica, Efstathios Papadakis, Gordana Matić, Danijela Vojnović Milutinović
OBJECTIVE: Most women with PCOS have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevation in urinary excretion of its metabolites. Increased cortisol clearance in PCOS is followed by a compensatory overdrive of the hypothalamic-pituitary-adrenocortical (HPA) axis …