Filippo Ceccato, Mattia Barbot, Marialuisa Zilio, Sergio Ferasin, Paola De Lazzari, Laura Lizzul, Marco Boscaro and Carla Scaroni
Objective: Measurement of cortisol levels in saliva is a marker of free hormone. How salivary cortisol rhythm is affected by age, gender, the metabolic syndrome and estrogen-progestin therapy was evaluated in a community sample of adults …
Krystallenia I. Alexandraki, Mohammed Munayem Khan, Harvinder S. Chahal, Nadezhda S. Dalantaeva, Giampaolo Trivellin, Dan M. Berney, Philippe Caron, Vera Popovic, Marija Pfeifer, Suzanne Jordan, Márta Korbonits, Ashley B. Grossman
OBJECTIVE: The model of “oncogene-induced senescence” (OIS), resulting in cell-proliferation arrest, has recently been suggested as a possible explanation for the non-progression of pituitary tumours to malignancy. The aim of the study was to compare the expression …
Emanuele Ferrante, Valentina Morelli, Claudia Giavoli, Giovanna Mantovani, Elisa Verrua, Elisa Sala, Elena Malcmiodi, Silvia Bergamaschi, Eriselda Profka, Elisa Cairoli, Serena Palmieri, Iacopo Chiodini, Andrea-Gerardo Lania, Anna Spada, Paolo Beck-Peccoz
OBJECTIVE: The diagnosis of hypothalamic-pituitary-adrenal insufficiency (HPAI) is a major clinical challenge. The gold standard procedure remains insulin tolerance test (ITT). This study aimed to evaluate the usefulness of standard-dose corticotrophin stimulation test (SDCT) in diagnosing HPAI …
Jean-Louis Wémeau, Emmanuelle Proust-Lemoine, Amélie Ryndak, Laura Vanhove
Christos M. Hatzis, Christopher Papandreou, Evridiki Patelarou, Constantine I. Vardavas, Eleni Kimioni, Dimitra Sifaki-Pistolla, Anna Vergetaki, Anthony G. Kafatos
OBJECTIVE: To identify the cardiovascular disease (CVD) risk-factor status and dietary habits of the surviving elderly participants of the initial Seven Countries Study (SCS) cohort and newly recruited middle-aged men from the same villages …
Eleni P. Kotanidou, Maria G. Grammatikopoulou, Bessie E. Spiliotis, Christina Kanaka-Gantenbein, Maria Tsigga, Assimina Galli-Tsinopoulou
OBJECTIVE: While the US today has the highest rates worldwide of obesity, Europe, and particularly Southern Europe, is catching up fast. The aim of this study was to report the prevalence of obesity in Greek children, aged 1-12 years. DESIGN: A systematic review—including all studies published in English and Greek …
Francesco Vierucci, Marta Del Pistoia, Paola Erba, Giovanni Federico, Giuseppe Saggese
OBJECTIVE. Bone health is a major concern in patients with Turner syndrome (TS). There are few studies assessing bone mineral status in TS adolescents and none have reported a clear relationship with the risk of fracture. We assessed bone mineral status at three different skeletal sites by two different …
Efi Koloverou, Nikolaos Tentolouris, Chryssa Bakoula, Christina Darviri, George Chrousos
OBJECTIVE: Although there is scientific evidence that stress adversely affects metabolic control, only a few studies have examined the role of stress management in improving glycemic control in patients with type 2 diabetes mellitus (DM). In this study, we investigated the effect of a relaxation technique on levels of stress and glycemic control …
Nektraria Papadopoulou-Marketou, Chrysanthi Skevaki, Ioanna Kosteria, Melpomeni Peppa, George P. Chrousos, Ioannis Papassotiriou, Christina Kanaka-Gantenbein
OBJECTIVE: Diabetic nephropathy constitutes a major long-term complication in patients with type 1 diabetes mellitus (T1D) and its diagnosis is based on microalbuminuria. The aim of this observational follow-up study was to explore the role of neutrophil-gelatinase-associated lipocalin (NGAL) and cystatin C in unravelling early diabetic nephropathy even in patients with normoalbuminuria …
Christos Tsatsanis, Eirini Dermitzaki, Pavlina Avgoustinaki, Niki Malliaraki, Vasilis Mytaras, Andrew N. Margioris
Adipose tissue produces factors, including adipokines, cytokines and chemokines which, when released, systemically exert endocrine effects on multiple tissues thereby affecting their physiology. Adipokines also affect the hypothalamic-pituitary-gonadal (HPG) axis both centrally, at the hypothalamic-pituitary level …
Corina Neamţu, Claudiu Ţupea, Diana Păun, Anca Hoisescu, Adina Ghemigian, Samuel Refetoff, Chutintorn Sriphrapradang
Thyroid hormones (TH) exert their actions by binding nuclear receptors alpha (TRα1) and beta (TRß1 and TRß2). Resistance to thyroid hormone (RTH) is a clinical syndrome with various clinical manifestations, its hallmark being decreased tissue sensitivity …
Kalliopi Pazaitou-Panayiotou, Athina Kaprara, Maria Boudina, Eleni Georgiou, Apostolos Drimonitis, Ekaterini Raptou, Grammati Galaktidou, Iraklis Vainas
OBJECTIVE: To define clinical presentation, surgical complications, follow-up characteristics, and survival of 23 children and adolescents with thyroid carcinoma. DESIGN: Retrospective analysis of data of 23 children and adolescents with thyroid carcinoma cared for in the Theagenion Cancer Hospital, Thessaloniki…
Themistoklis N. Spyridopoulos, Eleni Th. Petridou, Nick Dessypris, Agapios Terzidis, Alkistis Skalkidou, Charalambos Deliveliotis, George P. Chrousos and the Obesity and Cancer Oncology Group*
OBJECTIVE: Leptin is primarily produced in adipose tissue and appears to play a modulatory role between metabolism and immunity. Given that obesity, a state of chronic inflammation, is an established risk factor for Renal Cell Carcinoma (RCC), we investigated the association between plasma leptin levels and RCC risk …
Massimo Rizzo, Alessandro Sindoni, Raffaele Talamo Rossi, Orsola Bonaffini, Stefania Panetta, Claudio Scisca, Giuseppe Altavilla, Lucia Denaro, Antonio Rosanò, Giovanna Saraceno, Francesco Trimarchi, Salvatore Benvenga
Kyriakos Ioannou
Diabetic nephropathy is defined as a microvascular complication of the kidneys induced by diabetes mellitus and is characterized by albuminuria and progressive loss of kidney function. However, neither albuminuria nor glomerular filtration rate decline are diabetic nephropathy-specific markers, thus the diagnosis of diabetic nephropathy greatly …
Gerasimos Krassas, Nikolaos Pontikides, Argyrios Dumas, Jan Frystyk, Jian-WenChen, Allan Flyvbjerg
The aim of this study was to investigate the effect of long-term somatostatin analogue (SM-a) treatment on serum levels of free (F) and total (T) insulin-like growth factor (IGF)-I, -II and IGF binding protein (IGFBP) – 1, -2 and -3 in euthyroid patients with active thyroid ophthalmopathy. For this purpose, we measured the above-mentioned parameters …
Bessie E. Spiliotis, Theodore K. Alexandrides, Christoforos Karystianos, Pavlos Vassilakos, Zvi Zadik, Nikoleta M. Nikolakopoulou, George Nikiforidis, Nicholas G Beratis
OBJECTIVE: The aim of the study was to evaluate the IGF-I generation test (IGF-I gen) as a possible indirect test of Growth Hormone (GH) secretory status. METHODS: Sixty-five GH deficient (GHD 1 and 2) and 86 control children were studied …
Vassiliki Pelekanou, George Notas, Efstathios N. Stathopoulos, Elias Castanas, Marilena Kampa
Prostate cancer is one of the most common malignancies and causes of death among men in western societies. It has thus attracted the interest of the scientific community, which has resulted in great improvements in survival rates in recent years. As early as the 1940s, Huggins and Hodges first demonstrated that prostate cancer is androgen dependent …
Kai I. Cheang, Paulina Essah, John E. Nestler
Current evidence suggests that insulin resistance contributes to the pathophysiologic features of the polycystic ovary syndrome (PCOS). The observation that insulin resistance is a central feature of PCOS leads to studies of the insulin signaling system in this disorder. This article reviews the possible role of putative insulin mediators, inositolphosphoglycans (IPG) mediators, in PCOS. We will focus on how IPGs mediate (a) hyperandrogenism and (b) insulin sensitivity in this disorder…
Frangiskos Economou, Xenofon Xyrafis, Sarantis Livadas, Ioannis I. Androulakis, Georgia Argyrakopoulou, Charikleia D.Christakou, Eleni Kandaraki, Eleni Palioura, Evanthia Diamanti-Kandarakis
OBJECTIVE: To investigate liver enzymes in a cohort of women with Polycystic Ovary Syndrome (PCOS) and controls divided according to body mass index (BMI) and their association with features of the syndrome. DESIGN: Eighty-three PCOS women and 64 healthy women were studied. Patients and controls were subdivided into two groups …
Dimitrios Anyfantakis, Emmanouil K. Symvoulakis, Demosthenes B. Panagiotakos, Dimitrios Tsetis, Elias Castanas, Sue Shea, Maria Venihaki, Christos Lionis
OBJECTIVE: This study aimed at exploring to what extent psychosocial factors, such as religiosity/spirituality and sense of coherence, mediate the negative effects of stress on a variety of cardiometabolic indicators, i.e., hypertension, diabetes, cardiovascular and cerebrovascular disease, and atherosclerotic bio-clinical markers …
Nikos Yiannakouris, Labros Melistas, Mary Yannakoulia, Keisha Mungal, Christos S. Mantzoros
A common -2548G/A promoter variant of the human leptin gene has recently been shown to be associated with variations in circulating leptin levels but available data are still conflicting. The aim of this study was to explore potential associations between the -2548G/A polymorphism and adiposity-related variables, plasma total leptin levels …
Spyros Karras, Themistoklis Tzotzas, Gerasimos E. Krassas
Antithyroid drugs (ATD) are widely used by endocrinologists all over the world for the treatment of Graves’ disease (GD) in the general population and in lactating thyrotoxic mothers.1,2 Traditionally, these agents produce minor side effects (rash, fever, urticaria) in 5-10% of the treated patients …
Grigorios Rombopoulos, Magdalini Hatzikou, Dimitra Latsou, John Yfantopoulos
OBJECTIVE: To estimate the impact of hypoglycemia on the Quality of Life (QoL) and its prevalence in patients with type 2 diabetes mellitus (T2DM) in Greece. DESIGN: A cross-sectional epidemiological study was conducted in 6631 patients with T2DM …
Leonidas H. Duntas, Nikolaos Tsakalakos, Brigitte Grab-Duntas, Maria Kalarritou, Elli Papadodima
The introduction of human recombinant thyrotropin (rhTSH/Thyrogen) into the diagnosis of thyroid cancer has substantially ameliorated the patient’s quality of life through the avoidance of debilitating hypothyroidism. With the aim of updating the use of Thyrogen, we report 7 cases which were treated with Thyrogen for diagnostic or therapeutic purposes …